The research, published in the scientific journal Acta Neuropathologica, analyzed retinal and brain tissue samples from 86 individuals.
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A new study suggests that changes in the eyes can signal the development of cognitive diseases, including Alzheimer’s, years before the first symptoms appear. The research, published in the scientific journal Acta Neuropathologica, analyzed retinal and brain tissue samples from 86 people with the disease and mild cognitive decline over a 14-year period. According to the study authors, this is the largest retinal sample analyzed to date.
The study is the first to provide in-depth analyzes of protein profiles and the molecular, cellular, and structural effects of Alzheimer’s disease on the human retina, and how they correspond to changes in human retinas, research leader Maya Koronio Hamoui said in a statement. Retina, brain and cognitive function. Changes in the retina have been associated with changes in the parts of the brain responsible for memory, navigation, and time perception.
By comparing the samples to a control group, the researchers found significant increases in beta-amyloid, an important marker of Alzheimer’s disease, in individuals with the disease and cognitive decline. In addition, they also found that microglia, which are responsible for repairing and maintaining other cells, decreased by 80% in individuals with cognitive problems, as well as signs of inflammation.
The results were also evident in people with little or no cognitive symptoms, suggesting that these new eye tests may be useful in aiding early diagnosis of Alzheimer’s disease.
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Charlotte Whitmore is a contributor at Mediarunsearch.co.uk, covering a broad range of topics including news, politics, business, technology, sport, entertainment, and lifestyle. She focuses on delivering clear, balanced reporting and practical information that helps readers stay informed about current events and emerging developments. Her work highlights stories that matter to everyday audiences, with an emphasis on accuracy, relevance, and accessible journalism that keeps readers connected to the issues shaping the UK and beyond.