A team of researchers from the University of Coimbra in PortugalAnd the The area of the human brain called the posterior cingulate has been identified as the area where the first changes occurred Alzheimer’s diseaseThis would pave the way for early treatment of the disease.
The researchers found that, in posterior cingulateThree typical symptoms of early-stage Alzheimer’s occur: neuritis, a buildup of amyloid proteins (insoluble in the human body) and apparently compensatory neural activity as an area of the brain attempts to function to compensate for the functional deficit. given by others.
“The finding could have very important implications for future therapies, as it clearly defines the target of early change in the brain causing amnesia, which can be studied in a direct and focused manner in new therapeutic trials,” highlights a statement from the university.
One of the team’s coordinators, Miguel Castillo-Branco, explained that the results of this research – were published in the journal. Communication biology Paving the way for the development and testing of treatments to reduce the neuroinflammation present in the disease. “The region identified is important because it serves as a link for the short- and long-term memory processes that we know are critically affected by Alzheimer’s disease,” he said.
The discovery was demonstrated by a combination of advanced functional and brain imaging techniques, involving people in very early stages of the disease and other individuals with similar sociodemographic characteristics. The research was developed by a multidisciplinary team from the University of Coimbra and the Centro Hospitalar e Universitário de Coimbra. (EFE)
